Description

2'-Deoxy-2'-Fluoro-5-Methylcytidine is a fluorinated nucleoside analog, a key building block in medicinal chemistry and oligonucleotide synthesis. Its modified sugar moiety provides enhanced metabolic stability and binding affinity, making it a critical intermediate for the development of novel therapeutics. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the synthesis of antisense oligonucleotides, siRNA, and other advanced nucleic acid-based drugs.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used as a modified phosphoramidite monomer for incorporating 2'-fluoro-5-methylcytidine into antisense oligonucleotides and siRNA to enhance stability and efficacy.
• Biochemical Research: Serves as a valuable tool for studying RNA interference (RNAi) mechanisms, enzyme-substrate interactions, and nucleic acid metabolism.
• Prodrug Development: Employed in the design and synthesis of prodrugs aimed at improving the bioavailability and targeted delivery of nucleoside therapeutics.
• Diagnostic Probe Synthesis: Utilized in creating labeled probes for molecular diagnostics and genomic research applications.

Basic Information

Product Name	2'-Deoxy-2'-Fluoro-5-Methylcytidine
CAS No.	182495-80-3
Molecular Formula	C10H14FN3O4
Molecular Weight	259.24 g/mol
Synonyms	5-Methyl-2'-deoxy-2'-fluorocytidine; 2'-Fluoro-5-methyl-2'-deoxycytidine; 2'-F-5-Me-dC; 1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl)-5-methyl-1,2-dihydropyrimidine-2,4-dione; 5-Methyl-2'-fluoro-2'-deoxycytidine; 2'-F-5-Methylcytidine; FdC(5Me)
EINECS	Contact for details

Quality Control

We supply 2'-Deoxy-2'-Fluoro-5-Methylcytidine manufactured under strict quality systems. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. Our quality commitment supports applications requiring high-purity standards, such as GMP-grade pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.