Description

(2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-Fluoropyrimidin-4-Yl)-1-(1H-1,2,4-Triazol-1-Yl)Butan-2-Ol is a sophisticated chiral triazole derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical high-purity intermediate for the synthesis of novel antifungal agents, leveraging its unique fluorinated aromatic and heterocyclic structure. It is primarily sought by pharmaceutical R&D teams, contract research organizations (CROs), and fine chemical manufacturers engaged in developing next-generation therapeutic candidates.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of potent triazole-based antifungal APIs.
• Antifungal Drug Development: Core scaffold for research into new systemic and topical antifungal treatments targeting fungal CYP51.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize efficacy and pharmacokinetic profiles.
• Process Chemistry & Scale-Up: Serves as a reference standard and starting material for process development and optimization in GMP manufacturing.
• Biochemical Research: Potential tool compound for studying fungal enzyme inhibition and resistance mechanisms.
• Custom Synthesis: Basis for the preparation of novel analogs and derivatives for proprietary drug discovery programs.

Basic Information

Product Name	(2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-Fluoropyrimidin-4-Yl)-1-(1H-1,2,4-Triazol-1-Yl)Butan-2-Ol
CAS No.	182230-43-9
Molecular Formula	C16H12F3N5O
Molecular Weight	347.30 g/mol
Synonyms	Fluconazole Impurity; Fluconazole Related Compound; 2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (racemic); UNII-6V3V2P8G6H; Butan-2-ol, 2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)-; (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-Fluoropyrimidin-4-Yl)-1-(1H-1,2,4-Triazol-1-Yl)Butan-2-Ol; 6V3V2P8G6H
EINECS	Contact for details

Quality Control

Our (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-Fluoropyrimidin-4-Yl)-1-(1H-1,2,4-Triazol-1-Yl)Butan-2-Ol is produced under strict quality management systems to ensure high purity and batch-to-batch consistency, critical for pharmaceutical research. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is kept tightly sealed in a dry environment to prevent degradation and absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.