Description

Ombrabulin CAS NO 181816-48-8 is a synthetic small molecule compound belonging to the class of vascular disrupting agents (VDAs). This compound is of significant interest in pharmaceutical research and development due to its targeted mechanism of action on tumor vasculature. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology drug discovery and preclinical studies. Its unique properties make it a valuable tool for investigating novel cancer therapeutics.

Application

• Pharmaceutical Research & Development: Core component in the discovery and preclinical evaluation of new anti-cancer therapies.
• Oncology Drug Discovery: Used as a reference standard or active pharmaceutical ingredient (API) in studies targeting tumor blood vessel disruption.
• Biochemical Assay Development: Serves as a key reagent in developing and validating in vitro assays to screen for vascular disrupting activity.
• Mechanistic Studies: Employed in research to elucidate the pathways and effects of vascular disruption on solid tumors.
• Academic Research: Utilized in university and institutional labs for fundamental cancer biology and pharmacology research.
• Reference Standard: High-purity grades are used for analytical purposes, including HPLC, LC-MS calibration, and method validation.

Basic Information

Product Name	Ombrabulin
CAS No.	181816-48-8
Molecular Formula	C₂₀H₂₅N₅O₅
Molecular Weight	415.44 g/mol
Synonyms	AVE8062; AC-7700; Ombrabulin Hydrochloride; (1S,2S,3R,4S)-4-{[(1S)-2-Amino-1-(4-aminophenyl)ethyl]amino}-N,N-diethyl-1-{[(3R,4S,5S)-3-methoxy-1-{(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]pyrrolidin-1-yl}-5-methyl-1-oxoheptan-4-yl]carbamoyl}-2,3-dihydroxycyclopentane-1-carboxamide; AC7700; AVE 8062
EINECS	Contact for details

Quality Control

Our Ombrabulin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, identification by spectroscopic methods (IR, NMR, MS), and control of specified impurities. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥98.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.