Description

4-Amino-5-Fluoro-1-[(2S,5R)-5-(Hydroxymethyl)-2,5-Dihydrofuran-2-Yl]Pyrimidin-2-One is a high-purity, advanced pharmaceutical intermediate with a defined stereochemistry. This compound is critical for the synthesis of novel antiviral and anticancer agents, offering a key chiral building block for complex molecular architectures. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of nucleoside analog therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel antiviral drugs, particularly nucleoside analogs.
• Anticancer Agent R&D: Used in research and development for creating potential chemotherapeutic compounds targeting DNA/RNA synthesis.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	4-Amino-5-Fluoro-1-[(2S,5R)-5-(Hydroxymethyl)-2,5-Dihydrofuran-2-Yl]Pyrimidin-2-One
CAS No.	181785-84-2
Molecular Formula	C9H10FN3O3
Molecular Weight	227.19 g/mol
Synonyms	4-Amino-5-fluoro-1-[(2S,5R)-5-(hydroxymethyl)-2,5-dihydro-2-furanyl]-2(1H)-pyrimidinone; (2S,5R)-5-(Hydroxymethyl)-2,5-dihydrofuran-2-yl 4-Amino-5-fluoropyrimidin-2-one; 4-Amino-5-fluoro-1-((2S,5R)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)pyrimidin-2(1H)-one; A fluorinated dihydrofuran pyrimidinone intermediate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 4-Amino-5-Fluoro-1-[(2S,5R)-5-(Hydroxymethyl)-2,5-Dihydrofuran-2-Yl]Pyrimidin-2-One is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with research and pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and chiral identity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (2S,5R isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.