Description

tert-Butyl 4-Azidopiperidine-1-Carboxylate (Saltdata: Free) is a high-purity, protected piperidine derivative featuring a reactive azide functional group, making it a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring precise, reliable intermediates for constructing complex molecular architectures. It is primarily utilized in pharmaceutical R&D, agrochemical discovery, and materials science for applications such as click chemistry, peptide modification, and the synthesis of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those targeting the central nervous system.
• Click Chemistry Reagent: The azide group enables efficient, high-yielding Huisgen 1,3-dipolar cycloaddition reactions with alkynes to form triazole linkages, a cornerstone of bioconjugation and polymer chemistry.
• Peptidomimetics & PROTACs: Used to incorporate piperidine scaffolds and functional handles into peptide backbones and proteolysis-targeting chimeras (PROTACs) for drug discovery.
• Agrochemical Synthesis: Serves as a versatile intermediate in the development of novel herbicides, fungicides, and insecticides.
• Material Science: Employed in the functionalization of surfaces and polymers, and in the creation of novel cross-linked or smart materials.
• Chemical Biology Probes: Facilitates the labeling and study of biological targets through bioorthogonal chemistry techniques.

Basic Information

Product Name	tert-Butyl 4-Azidopiperidine-1-Carboxylate (Saltdata: Free)
CAS No.	180695-80-1
Molecular Formula	C10H18N4O2
Molecular Weight	226.28 g/mol
Synonyms	1-Boc-4-azidopiperidine; 4-Azido-1-(tert-butoxycarbonyl)piperidine; tert-Butyl 4-azidopiperidine-1-carboxylate; 1-N-Boc-4-azidopiperidine; 4-Azidopiperidine-1-carboxylic acid tert-butyl ester; Boc-4-azidopiperidine; Piperidine-1-carboxylic acid, 4-azido-, 1,1-dimethylethyl ester; 180695-80-1
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Azidopiperidine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.