Description

1-(B-D-2-Deoxyribofuranosyl)-4-Methylindole is a specialized nucleoside derivative, a key building block in the synthesis of modified oligonucleotides. This compound matters for its role in advanced research and development, particularly in creating probes and therapeutic agents with tailored biological properties. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on nucleic acid chemistry, antisense technology, and drug discovery.

Application

• Oligonucleotide Synthesis: A critical intermediate for the solid-phase or solution-phase synthesis of modified DNA strands.
• Antisense & siRNA Research: Used to incorporate specific modifications into oligonucleotides for stability and target-binding studies in therapeutic development.
• Molecular Probe Development: Serves as a building block for creating fluorescent or affinity-labeled nucleotide probes for diagnostics and bioimaging.
• Structural Biology Studies: Employed to investigate nucleic acid structure, function, and protein-nucleic acid interactions.
• Pharmaceutical Intermediates: Acts as a precursor in the synthesis of novel nucleoside-based antiviral or anticancer drug candidates.
• Bioconjugation Chemistry: Provides a reactive handle for attaching various reporter groups or delivery vehicles to oligonucleotides.

Basic Information

Product Name	1-(B-D-2-Deoxyribofuranosyl)-4-Methylindole
CAS No.	180420-84-2
Molecular Formula	C14H17NO4
Molecular Weight	263.29 g/mol
Synonyms	4-Methylindole-1-β-D-2'-deoxyribofuranoside; 4-Methyl-1-(2-deoxy-β-D-ribofuranosyl)indole; 1-(2-Deoxy-β-D-ribofuranosyl)-4-methyl-1H-indole; 4-Methylindole deoxyribonucleoside; 4-Methyl-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1H-indole; d4MI; 4-Methyldeoxyinosine analog
EINECS	Contact for details

Quality Control

Our 1-(B-D-2-Deoxyribofuranosyl)-4-Methylindole is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.