Description

3'-β-C-Ethynylguanosine is a modified nucleoside analog featuring an ethynyl group at the 3'-beta position of the ribose sugar. This structural modification is critical for its role as a key pharmaceutical intermediate and research chemical in the development of novel antiviral and anticancer therapeutics. It is primarily utilized by research institutions and pharmaceutical companies engaged in nucleoside chemistry and drug discovery. The compound, identified by CAS number 180300-56-5, is essential for synthesizing advanced nucleotide prodrugs and investigating mechanisms of viral polymerase inhibition.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of next-generation antiviral drugs, particularly those targeting RNA viruses.
• Antiviral Research: Used in biochemical studies to investigate the inhibition mechanisms of viral polymerases (e.g., HCV, SARS-CoV-2).
• Nucleoside Analog Development: Serves as a precursor for creating prodrugs with enhanced cellular uptake and metabolic stability.
• Oncology Research: Investigated for its potential incorporation into oligonucleotides or as a cytotoxic agent in cancer cell studies.
• Biochemical Tool: Employed in enzymatic assays to study substrate specificity and kinetics of nucleoside-processing enzymes.
• Process Chemistry & Scale-Up: Used in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	3'-β-C-Ethynylguanosine
CAS No.	180300-56-5
Molecular Formula	C₁₂H₁₃N₅O₅
Molecular Weight	307.26 g/mol
Synonyms	3'-C-Ethynylguanosine; 3'-β-C-Ethynylguanosine; 9-[(2R,3R,4S,5R)-3-Ethynyl-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,9-dihydro-6H-purin-6-one; Guanosine, 3'-C-ethynyl-; 3'-Ethynyl-G; 3'-C-Ethynyl-Guo; 3'-β-Ethynylguanosine; 3'-Ethynylguanosine
EINECS	Contact for details

Quality Control

Our 3'-β-C-Ethynylguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP intermediate specifications. Custom purity grades and analytical packages are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Long-term storage at -20°C is recommended for optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.