Description

3'-β-C-Ethynyladenosine is a chemically modified nucleoside analog, distinguished by its ethynyl group at the 3'-beta position of the ribose sugar. This structural modification is critical for its role as a key intermediate in the synthesis of novel antiviral and anticancer nucleotide analogs, offering researchers a versatile building block for drug discovery. It is essential for pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing next-generation therapeutics targeting viral polymerases and cellular enzymes.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of potent nucleoside reverse transcriptase inhibitors (NRTIs) for antiviral research.
• Antiviral Drug Development: Used in the design and production of experimental compounds targeting viruses such as HIV, Hepatitis B, and other retroviruses.
• Oncology Research: Serves as a building block for creating nucleotide analogs that inhibit cancer cell proliferation by interfering with DNA/RNA synthesis.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to understand polymerase mechanisms and nucleotide metabolism.
• Prodrug Synthesis: Utilized to develop prodrug forms of nucleoside analogs, enhancing bioavailability and targeted delivery.
• Labeled Compound Production: Acts as a starting material for synthesizing isotopically labeled (e.g., C-13, N-15) compounds for metabolic tracing and pharmacokinetic studies.

Basic Information

Product Name	3'-β-C-Ethynyladenosine
CAS No.	180300-54-3
Molecular Formula	C12H13N5O4
Molecular Weight	291.26 g/mol
Synonyms	3'-C-ethynyladenosine; 3'-β-C-Ethynyladenosine; 9-[(2R,3R,4S,5R)-3-Ethynyl-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-amine; 3'-C-Ethynyl-Ado; Adenosine, 3'-C-ethynyl-; 3'-Ethynyladenosine; 3'-C-Ethynyl-adenosine
EINECS	Contact for details

Quality Control

Our 3'-β-C-Ethynyladenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.