Description

5-(1-Propynyl)-2'-o-Methylcytidine is a chemically modified nucleoside analog, a key building block in advanced oligonucleotide synthesis. This compound matters for its role in creating therapeutic nucleic acids with enhanced stability and target specificity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of antisense oligonucleotides, siRNA, and other next-generation genetic medicines.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A critical phosphoramidite precursor for constructing oligonucleotides designed to modulate gene expression.
• siRNA and miRNA Therapeutics: Used in the solid-phase synthesis of RNA strands to improve nuclease resistance and pharmacokinetic properties.
• Medicinal Chemistry Research: Serves as a versatile intermediate for exploring structure-activity relationships (SAR) in nucleoside-based drug discovery.
• Diagnostic Probe Development: Incorporated into labeled probes for sensitive detection of specific DNA or RNA sequences.
• Bioconjugation and Labeling: The propynyl group provides a handle for further chemical modifications, such as click chemistry, for attaching fluorophores or other functional groups.

Basic Information

Product Name	5-(1-Propynyl)-2'-o-Methylcytidine
CAS No.	179817-96-0
Molecular Formula	C13H17N3O5
Molecular Weight	295.29 g/mol
Synonyms	2'-O-Methyl-5-(1-propynyl)cytidine; 5-Propynyl-2'-O-methylcytidine; 2'-O-Me-5-propynyl-C; N4-Benzoyl-5-(1-propynyl)-2'-O-methylcytidine (protected form); 5-(Prop-1-yn-1-yl)-2'-O-methylcytidine; 2'-O-Methyl-5-propynylcytidine; 1-((2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl)-5-prop-1-ynylpyrimidine-2,4-dione
EINECS	Contact for details

Quality Control

Our 5-(1-Propynyl)-2'-o-Methylcytidine is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.