Description

(S)-Chlophedianol is the single enantiomer of the antitussive agent chlophedianol, characterized by its specific stereochemistry at the chiral center. This high-purity enantiomer is critical for advanced pharmaceutical research and development, particularly in the study of stereospecific drug activity and receptor interactions. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) for developing new or improved cough suppressant formulations.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of enantiomerically pure antitussive (cough suppressant) drugs.
• Pharmacological Research: Used in preclinical studies to investigate the specific biological activity, metabolism, and pharmacokinetics of the (S)-enantiomer compared to its racemic mixture or the (R)-enantiomer.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation of chiral separation techniques like HPLC or CE.
• API Development: Integral to the development and scale-up of new stereospecific active pharmaceutical ingredients targeting the central nervous system.
• Academic & Institutional Research: Supports chemical and pharmacological research in universities and institutes focusing on chirality, medicinal chemistry, and drug discovery.

Basic Information

Product Name	(S)-Chlophedianol
CAS No.	179764-49-9
Molecular Formula	C12H16ClNO
Molecular Weight	225.72 g/mol
Synonyms	(S)-2-Chloro-α-(2-(dimethylamino)ethyl)benzhydrol; (S)-Chlorphenedianol; (S)-Clofedanol; (S)-ULO; Dexclofedianol; (S)-2-Chloro-α-[2-(dimethylamino)ethyl]benzhydrol; (S)-Chlophedianol Hydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our (S)-Chlophedianol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity, chemical purity, and identity confirmation. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates, and specifications can be aligned with client-specific pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere when appropriate to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.