Description

2-Chloro-6-Fluorophenylacetyl Chloride is a versatile and reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in enabling the efficient introduction of the 2-chloro-6-fluorophenylacetyl moiety, a key structural motif for modulating biological activity and material properties. This high-purity intermediate is essential for research and production within the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the chloro-fluoro substitution pattern enhances efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptide Mimetics and Bioconjugation: Facilitates the acylation of amines in peptides or biomolecules to create stable amide bonds for drug conjugates or probes.
• Polymer and Material Science: Employed in the production of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Custom Synthesis and R&D: A valuable reagent for contract research organizations (CROs) and academic laboratories exploring new chemical entities and reaction methodologies.

Basic Information

Item	Details
Product Name	2-Chloro-6-Fluorophenylacetyl Chloride
CAS No.	179314-61-5
Molecular Formula	C8H5Cl2FO
Molecular Weight	207.03 g/mol
Synonyms	2-Chloro-6-fluorophenylacetyl chloride; (2-Chloro-6-fluorophenyl)acetyl chloride; 2-Chloro-6-fluoro-α-chloroacetophenone; 2-Chloro-6-fluorobenzeneacetyl chloride; α-Chloro-2-chloro-6-fluoroacetophenone; 2-Chloro-6-fluorophenacyl chloride; NSC 405124; 179314-61-5
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-Fluorophenylacetyl Chloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the stringent requirements of our global clientele. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Density (at 20°C)	~1.4 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.