Description

Benzenemethanol, α-Ethynyl-3-Fluoro-, (R)- (9Ci) is a high-value, chiral fluorinated building block of significant interest in advanced organic synthesis. This compound matters because its unique structure, featuring both an ethynyl group and a fluorine atom on a chiral benzyl alcohol scaffold, enables the precise construction of complex molecules with tailored properties. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, particularly where stereochemistry and fluorine substitution are critical for biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and oncology drug candidates.
• Agrochemical Synthesis: Used in the creation of advanced, fluorinated pesticides and herbicides where the stereocenter can influence biological efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis, leveraging the propargylic alcohol and fluorine motifs.
• Material Science Research: Employed in the synthesis of specialty monomers or advanced organic materials that require fluorinated, rigid aromatic components.
• Chemical Biology Probes: Utilized as a building block for fluorescent tags or molecular probes where the alkyne handle allows for click chemistry conjugation.

Basic Information

Product Name	Benzenemethanol, α-Ethynyl-3-Fluoro-, (R)- (9Ci)
CAS No.	179249-17-3
Molecular Formula	C9H7FO
Molecular Weight	150.15 g/mol
Synonyms	(R)-3-Fluoro-α-ethynylbenzenemethanol; (R)-1-(3-Fluorophenyl)-2-propyn-1-ol; (R)-α-Ethynyl-3-fluorobenzyl alcohol; (R)-3-Fluoro-α-ethynylbenzyl alcohol; (R)-3-Fluorophenyl(prop-2-yn-1-yl)methanol; (R)-1-(3-Fluorophenyl)prop-2-yn-1-ol; (R)-FPEA alcohol; (R)-3-Fluoro-α-ethynyl-benzenemethanol (9CI)
EINECS	Contact for details

Quality Control

Our Benzenemethanol, α-Ethynyl-3-Fluoro-, (R)- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure high chemical and optical purity suitable for sensitive synthetic applications. Comprehensive Certificates of Analysis (COA) with full chromatographic data are provided to support your R&D and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). Keep the container tightly sealed under an inert atmosphere if prolonged storage is required to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.