Description

Egfr/Erbb-2 Inhibitor CAS NO 179248-61-4 is a potent and selective small molecule compound designed to target and inhibit the epidermal growth factor receptor (EGFR) and ErbB-2 (HER2) tyrosine kinase pathways. This dual inhibition is critical for disrupting aberrant signaling cascades that drive uncontrolled cellular proliferation in various disease states. It is an essential research-grade biochemical for pharmaceutical R&D, academic institutions, and biotechnology companies focused on oncology, signal transduction research, and novel therapeutic development.

Application

• Pharmaceutical Research & Development (R&D): Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the discovery and development of targeted cancer therapies.
• Biochemical & Cell-Based Assays: Used as a selective inhibitor to study EGFR/HER2 signaling pathways, mechanism of action, and drug resistance in vitro.
• Academic Research: A vital tool for investigating the role of receptor tyrosine kinases in cancer biology, cellular differentiation, and apoptosis.
• Preclinical Studies: Employed in animal models to evaluate the efficacy, pharmacokinetics, and toxicity profiles of EGFR/HER2-targeting drug candidates.
• High-Throughput Screening (HTS): Utilized in compound libraries for screening campaigns to identify novel inhibitors or synergistic drug combinations.

Basic Information

Product Name	Egfr/Erbb-2 Inhibitor
CAS No.	179248-61-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	EGFR/ErbB-2 Inhibitor; EGFR/HER2 Inhibitor; Tyrosine Kinase Inhibitor (TKI); 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline (core structural analog class); Erlotinib/Canertinib analog; Quinazoline-based EGFR inhibitor; Protein Kinase Inhibitor
EINECS	Contact for details

Quality Control

Our Egfr/Erbb-2 Inhibitor is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.