Description

3’,5’-Bis(o-T-Butyldimethylsilyl)-4’-C-Hydroxymethyl Thymidine is a sophisticated, nucleoside-derived building block specifically engineered for advanced organic synthesis. This compound is critical for researchers and manufacturers requiring high-purity intermediates in the development of complex molecules. It is primarily utilized in the pharmaceutical and biotechnology sectors for applications such as oligonucleotide synthesis and prodrug development, where precise chemical modification is paramount.

Application

• Oligonucleotide Synthesis: Serves as a key protected intermediate in the solid-phase synthesis of modified DNA and RNA strands for research and therapeutic applications.
• Antiviral Prodrug Development: Used as a precursor in the synthesis of nucleoside analogs, which are investigated as potential antiviral and anticancer agents.
• Medicinal Chemistry Research: Acts as a versatile building block for creating novel nucleoside derivatives to explore new structure-activity relationships.
• Bioconjugation: The hydroxymethyl group provides a handle for further functionalization, enabling conjugation with other molecules like fluorophores or targeting ligands.
• Chemical Biology Probes: Utilized in the creation of labeled or modified nucleosides to study biological processes and mechanisms.
• Process Development & Scale-up: Supplied as a high-purity intermediate for optimizing and scaling the production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	3’,5’-Bis(o-T-Butyldimethylsilyl)-4’-C-Hydroxymethyl Thymidine
CAS No.	179178-45-1
Molecular Formula	C23H44N2O6Si2
Molecular Weight	500.78 g/mol
Synonyms	4'-C-Hydroxymethyl-3',5'-bis-O-(tert-butyldimethylsilyl)thymidine; 3',5'-Di-O-(tert-butyldimethylsilyl)-4'-C-(hydroxymethyl)thymidine; 4'-C-Hydroxymethylthymidine 3',5'-bis-TBDMS ether; TBDMS-protected 4'-C-Hydroxymethyl Thymidine; 4'-C-(Hydroxymethyl)-3',5'-bis-O-[(1,1-dimethylethyl)dimethylsilyl]thymidine
EINECS	Contact for details

Quality Control

Every batch of 3’,5’-Bis(o-T-Butyldimethylsilyl)-4’-C-Hydroxymethyl Thymidine is produced and tested under strict quality management systems. We ensure compliance with high-purity standards suitable for pharmaceutical research and development. Comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, is performed to verify identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions, such as in a nitrogen atmosphere or desiccator, to prevent degradation. Keep away from fluoride sources and strong alkali.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.