Description

Timcodar CAS NO 179033-51-3 is a potent and selective small molecule inhibitor of P-glycoprotein (P-gp), a key efflux transporter associated with multidrug resistance (MDR) in cancer cells. This compound matters because it offers a promising strategy to enhance the intracellular accumulation and efficacy of chemotherapeutic agents, potentially overcoming treatment failure in resistant tumors. It is primarily needed by pharmaceutical researchers and manufacturers in the oncology and drug development sectors for preclinical studies and combination therapy formulations.

Application

• Multidrug Resistance (MDR) Reversal Agent: Used in research to inhibit P-glycoprotein and restore sensitivity to chemotherapeutic drugs like doxorubicin, paclitaxel, and vinblastine in resistant cancer cell lines.
• Oncology Research: A critical tool for in vitro and in vivo studies aimed at understanding and overcoming mechanisms of chemoresistance in various cancers.
• Drug Delivery Enhancement: Investigated in formulation development to improve the bioavailability and therapeutic index of co-administered anticancer drugs.
• Pharmacokinetic Studies: Employed to study the role of P-gp in drug absorption, distribution, and excretion, influencing ADME (Absorption, Distribution, Metabolism, and Excretion) profiles.
• Biochemical Assays: Serves as a reference standard and active pharmaceutical ingredient (API) in high-throughput screening and functional assays targeting ABC transporters.

Basic Information

Product Name	Timcodar
CAS No.	179033-51-3
Molecular Formula	C₂₆H₂₈N₄O₃
Molecular Weight	444.53 g/mol
Synonyms	VX-853; VX 853; Timcodar (VX-853); N-[2-[(2R)-2-[(3S)-3-(Aminomethyl)-1-pyrrolidinyl]-2-oxoethyl]-1,3-benzodioxol-5-yl]-2-(trifluoromethyl)benzamide; Benzamide, N-[2-[(2R)-2-[(3S)-3-(aminomethyl)-1-pyrrolidinyl]-2-oxoethyl]-1,3-benzodioxol-5-yl]-2-(trifluoromethyl)-; (R)-N-(2-(1,3-Benzodioxol-5-yl)-2-oxoethyl)-N-(3-(aminomethyl)pyrrolidinyl)-2-(trifluoromethyl)benzamide
EINECS	Contact for details

Quality Control

Our Timcodar is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-grade research standards. A comprehensive Certificate of Analysis (COA) detailing purity, residual solvents, and other critical parameters is provided with each shipment to guarantee traceability and consistency for your research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.