Description

Azide-Peg3-Tos is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an azide group and a tosylate leaving group, separated by a triethylene glycol spacer. This compound is a critical reagent in click chemistry, specifically for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, enabling the efficient and selective conjugation of biomolecules and synthetic polymers. It is essential for researchers and manufacturers in pharmaceutical development, bioconjugation, and materials science who require reliable, high-purity linkers for constructing complex molecular architectures.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Synthesis: Used to attach cytotoxic drugs, fluorescent dyes, or other payloads to antibodies, proteins, or peptides via the azide functional group.
• Polymer and Materials Functionalization: Serves as a key building block for modifying polymer backbones or nanoparticle surfaces to introduce azide handles for further click chemistry modifications.
• Proteomics and Chemical Biology: Enables the site-specific labeling of biomolecules for studies involving protein interaction, localization, and activity.
• Diagnostic Reagent Development: Utilized in the creation of diagnostic assays and imaging probes where stable, covalent linkages are required.
• Solid-Phase Peptide Synthesis (SPPS): Acts as a versatile linker for the synthesis of peptide conjugates on solid support.
• Surface Immobilization: Facilitates the covalent attachment of molecules to surfaces (e.g., chips, beads) for biosensor and microarray applications.

Basic Information

Product Name	Azide-Peg3-Tos
CAS No.	178685-33-1
Molecular Formula	C16H25N3O6S
Molecular Weight	387.45 g/mol
Synonyms	1-Azido-2-(2-(2-(2-(p-toluenesulfonyloxy)ethoxy)ethoxy)ethoxy)ethane; 3,6,9-Trioxa-12-azatetradec-13-ene-1,14-diol, 12-azido-14-(4-methylbenzenesulfonate); PEG3-Azide-Tosylate; Azido-PEG3-OTs; Tosyl-PEG3-Azide; 2,5,8,11-Tetraoxatetradecan-14-yl 4-methylbenzenesulfonate, 13-azido-; Azido-PEG3-tosylate; N3-PEG3-OTs
EINECS	Contact for details

Quality Control

Every batch of Azide-Peg3-Tos is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from NMR (1H, 13C), HPLC, and mass spectrometry. Our quality commitment aligns with the standards required for research and cGMP-grade applications in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. The product is moisture-sensitive and should be handled under anhydrous conditions when possible. Allow the vial to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (NMR)	Complies
Identification (MS)	Complies
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.