Description

1,2-Dioctanoyl-Sn-Glycero-3-Phosphate is a synthetic, enantiomerically pure phospholipid derivative, specifically a phosphatidic acid analogue with defined medium-chain fatty acids. This precise chemical structure is critical for research and development in advanced lipid-based systems, offering a valuable tool for modulating membrane properties and studying lipid-protein interactions. It is primarily utilized by scientists and product developers in the pharmaceutical, biotechnology, and advanced materials sectors for applications ranging from liposome formulation to biochemical signaling studies.

Application

• Lipid Nanoparticle (LNP) & Liposome Research: Serves as a component or structural modifier in the development of novel drug delivery vehicles for mRNA, siRNA, and other therapeutic agents.
• Biochemical & Cell Biology Studies: Used as a substrate, inhibitor, or signaling molecule analog to investigate phospholipase activity, lipid metabolism, and intracellular signaling pathways.
• Membrane Biophysics: Employed in model membrane systems (e.g., vesicles, bilayers) to study the effects of specific lipid structures on membrane fluidity, curvature, and phase behavior.
• Pharmaceutical Excipient Development: Explored as a potential functional excipient in advanced formulations to enhance stability or modify drug release profiles.
• Reference Standard: Provides a high-purity standard for analytical method development and quality control in lipidomics and related fields.
• Material Science: Investigated for creating functionalized surfaces or bio-inspired materials due to its amphiphilic nature.

Basic Information

Product Name	1,2-Dioctanoyl-Sn-Glycero-3-Phosphate
CAS No.	178603-80-0
Molecular Formula	C19H37O8P
Molecular Weight	424.47 g/mol
Synonyms	1,2-Di-O-octanoyl-sn-glycero-3-phosphate; PA(8:0/8:0); 1,2-Dicapryloyl-sn-glycero-3-phosphate; sn-Glycerol-3-phosphate 1,2-dioctanoate; Phosphatidic Acid(16:0) (referring to total carbon chain length); Dioctanoyl Phosphatidic Acid; 1,2-Di-O-octanoyl-rac-glycerol-3-phosphate (racemic mixture); Octanoic acid, 1,2,3-propanetriyl ester, mono(dihydrogen phosphate) (C8:0 specific)
EINECS	Contact for details

Quality Control

Our 1,2-Dioctanoyl-Sn-Glycero-3-Phosphate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and enantiomeric excess, NMR for structural confirmation, and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality system supports cGMP standards for pharmaceutical development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). For long-term storage, keep under an inert atmosphere (argon or nitrogen). Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Enantiomeric Purity	≥ 98% sn-1,2 isomer
Water Content (KF)	≤ 2.0%
Solubility	Soluble in chloroform, methanol, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.