Description

2' 3'-Dideoxyadenosine 5'-Triphosphate S is a chemically modified nucleotide analog, specifically a dideoxyadenosine triphosphate (ddATP) derivative. This compound is a critical reagent in molecular biology research, primarily serving as a chain terminator in DNA sequencing and analysis techniques. It is essential for researchers and manufacturers in the fields of genomics, diagnostics, and pharmaceutical development who require high-purity, reliable nucleotide substrates. Our supply ensures consistent quality for sensitive applications where precision is paramount.

Application

• Sanger DNA Sequencing: Acts as a chain-terminating substrate in dideoxy sequencing reactions.
• Next-Generation Sequencing (NGS): Used in specialized protocols requiring modified nucleotide terminators.
• PCR-based Diagnostics: Employed in assays designed to detect specific genetic mutations or pathogens.
• Enzymatic Synthesis: Serves as a building block for the enzymatic synthesis of oligonucleotides or DNA probes.
• Biochemical Research: Used in studies of DNA polymerase kinetics, fidelity, and inhibition.
• Antiviral Research: Investigated as a potential nucleotide analog for probing viral reverse transcriptase mechanisms.

Basic Information

Product Name	2' 3'-Dideoxyadenosine 5'-Triphosphate S
CAS No.	178451-61-1
Molecular Formula	C10H15N5O12P3S
Molecular Weight	546.24 g/mol
Synonyms	ddATP-S; 2',3'-Dideoxyadenosine-5'-triphosphate, thio analog; Adenosine, 2',3'-dideoxy-5'-(trihydrogen triphosphate), 5'→5'-ester with 3-sulfanyl-1-propanol; 2',3'-Dideoxyadenosine 5'-(trihydrogen triphosphate) 5'-ester with 3-mercapto-1-propanol; Thiol-modified ddATP; S-ddATP; Chain-terminating nucleotide triphosphate
EINECS	Contact for details

Quality Control

Our 2' 3'-Dideoxyadenosine 5'-Triphosphate S is manufactured under strict quality systems to ensure it meets the high standards required for life science research. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every lot to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.