Description

2',3'-Dideoxy-3'-Fluoro-A-D-Uridine is a fluorinated nucleoside analog, a key building block in medicinal chemistry and life science research. This modified nucleoside is valued for its role in the synthesis of novel antiviral and anticancer agents, particularly as a precursor for probing nucleic acid interactions and enzyme mechanisms. It is essential for pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on developing nucleoside-based therapeutics and diagnostic tools.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of experimental antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand polymerase and reverse transcriptase mechanisms.
• Probe Development: Serves as a building block for creating fluorescent or radiolabeled probes for nucleic acid detection and imaging.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Antiviral Agent Synthesis: Specifically utilized in the research and development of dideoxynucleoside analogs targeting viral replication.

Basic Information

Product Name	2',3'-Dideoxy-3'-Fluoro-A-D-Uridine
CAS No.	178374-44-2
Molecular Formula	C9H11FN2O5
Molecular Weight	246.20 g/mol
Synonyms	3'-Fluoro-2',3'-dideoxyuridine; 2',3'-Dideoxy-3'-fluorouridine; 3'-F-ddU; 1-((2R,4S,5R)-4-Fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 3'-Fluoro-2',3'-dideoxy-A-D-uridine; 3'-F-2',3'-ddU; FDDU; 178374-44-2
EINECS	Contact for details

Quality Control

Our 2',3'-Dideoxy-3'-Fluoro-A-D-Uridine is manufactured under strict quality systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.