Description

Darusentan CAS NO 178306-46-2 is a potent and selective endothelin A (ETA) receptor antagonist. This compound is of significant interest in pharmaceutical research and development, particularly for its potential therapeutic applications in cardiovascular diseases. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in drug discovery and preclinical studies.

Application

• Primary research tool for studying the endothelin system and its role in cardiovascular physiology and pathology.
• Investigational pharmaceutical intermediate in the development of novel treatments for hypertension and pulmonary arterial hypertension (PAH).
• Reference standard for analytical method development and validation in pharmacokinetic and bioanalytical studies.
• Key material for preclinical efficacy and safety evaluations in animal models of vascular and renal diseases.
• Used in biochemical assays to characterize ETA receptor binding affinity and selectivity profiles.

Basic Information

Product Name	Darusentan
CAS No.	178306-46-2
Molecular Formula	C29H32N4O6
Molecular Weight	532.59 g/mol
Synonyms	Darusentan; LU 135252; LU-135252; (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-3-pyrrolidinecarboxylic Acid; 1-[2-[Dibutylamino]-2-oxoethyl]-4-(1,3-benzodioxol-5-yl)-2-(4-methoxyphenyl)-3-pyrrolidinecarboxylic Acid
EINECS	Contact for details

Quality Control

Our Darusentan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity analysis, identity confirmation (IR, MS), and determination of residual solvents and moisture content. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.