Description

Cyclic Adenosine Diphosphate-Ribose Phosphate is a specialized nucleotide derivative that serves as a critical second messenger in intracellular calcium signaling pathways. This compound is essential for researchers and developers in life sciences, enabling the study and modulation of calcium-dependent cellular processes. It is primarily utilized in biochemical research, pharmaceutical development, and as a high-purity reference standard for analytical purposes.

Application

• Biochemical Research: A key tool for investigating calcium release mechanisms mediated by ryanodine receptors (RyRs) in various cell types.
• Pharmaceutical R&D: Used in target validation and screening assays for developing novel therapeutics targeting cardiovascular, neurological, and metabolic disorders.
• Cell Signaling Studies: Essential for elucidating the role of cyclic ADP-ribose and its phosphorylated analogs in cellular communication and homeostasis.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in HPLC, LC-MS, and other chromatographic techniques.
• Enzymology: Used as a substrate or modulator in studies of ADP-ribosyl cyclases, CD38, and other related enzymes.

Basic Information

Product Name	Cyclic Adenosine Diphosphate-Ribose Phosphate
CAS No.	177966-53-9
Molecular Formula	C15H21N5O16P3
Molecular Weight	668.27 g/mol
Synonyms	cADPR-P; Cyclic ADP-ribose phosphate; 2'-Phospho-cyclic ADP-ribose; Adenosine 5'-(trihydrogen diphosphate), P-2-(1-(5-O-phosphono-β-D-ribofuranosyl)-1H-imidazol-4-yl)-2,5'-anhydro-, (1S)-; 2'-Phospho-cyclic adenosine diphosphoribose; cADPR 2'-phosphate; Cyclic ADP-ribose 2'-phosphate
EINECS	Contact for details

Quality Control

Our Cyclic Adenosine Diphosphate-Ribose Phosphate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant guidelines for research-grade biochemicals, with specifications available to meet the stringent requirements of pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep desiccated under an inert atmosphere. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.