Description

2'-Fluoromethylene-2'-Deoxycytidine 5'-Diphosphate is a chemically modified nucleotide analog, specifically a fluorinated cytidine diphosphate derivative. This compound is a critical building block in medicinal chemistry and biochemistry research, valued for its role in probing enzyme mechanisms and developing novel therapeutic agents. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on antiviral drug discovery, enzyme inhibition studies, and nucleic acid metabolism research.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly for DNA/RNA polymerases and kinases.
• Antiviral Drug Development: Serves as a key intermediate or active metabolite in the synthesis of nucleoside analog prodrugs targeting viral replication.
• Mechanistic Probes: Employed to study the structure-activity relationships (SAR) and metabolic pathways of fluorinated nucleosides.
• Labeled Compound Synthesis: Acts as a precursor for the synthesis of radiolabeled or fluorescently tagged nucleotides for diagnostic assays.
• Enzyme Kinetics: Utilized in high-throughput screening (HTS) to identify and characterize novel enzyme inhibitors.
• Academic Research: Fundamental tool for investigating nucleic acid biochemistry and cellular signaling pathways in university laboratories.

Basic Information

Item	Detail
Product Name	2'-Fluoromethylene-2'-Deoxycytidine 5'-Diphosphate
CAS No.	177956-38-6
Molecular Formula	C10H15FN3O11P2
Molecular Weight	425.19 g/mol
Synonyms	2'-Fluoromethylene-2'-deoxycytidine-5'-diphosphate; 2'-C-fluoromethylene-2'-deoxycytidine 5'-diphosphate; 2'-Fluoromethylene-dCydDP; FMdCydDP; 1-(2-Deoxy-2-fluoromethylene-β-D-erythro-pentofuranosyl)cytosine 5'-diphosphate; 2'-Deoxy-2'-fluoromethylenecytidine 5'-diphosphate; β-2'-Deoxy-2'-(fluoromethylene)cytidine-5'-diphosphate
EINECS	Contact for details

Quality Control

Our production of 2'-Fluoromethylene-2'-Deoxycytidine 5'-Diphosphate adheres to stringent quality protocols suitable for research and development applications. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure high chemical purity and structural identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your critical research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or moisture will compromise stability and purity. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by UV)
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.