Description

(R)-Rabeprazole CAS NO 177795-60-7 is the single enantiomer form of the proton pump inhibitor rabeprazole, specifically targeting the (R)-configuration. This high-purity chiral intermediate is critical for the development and manufacturing of enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and manufacturers engaged in the synthesis of novel therapeutics, particularly where stereoselective activity is required for enhanced efficacy and reduced side-effect profiles.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of enantiomerically pure rabeprazole and related proton pump inhibitor APIs.
• Research & Development: Used in pharmacological studies to investigate the specific biological activity and metabolic pathways of the (R)-enantiomer.
• Process Chemistry: Serves as a reference standard and starting material for developing and optimizing asymmetric synthesis routes.
• Analytical Standard: Employed as a high-purity standard for method development and quality control (HPLC, Chiral Chromatography) in pharmaceutical analysis.
• Drug Discovery: A valuable scaffold for medicinal chemists exploring new chemical entities with gastroprotective activity.

Basic Information

Product Name	(R)-Rabeprazole
CAS No.	177795-60-7
Molecular Formula	C18H20N3NaO3S
Molecular Weight	381.42 g/mol
Synonyms	(R)-Rabeprazole Sodium; Rabeprazole (R)-Enantiomer; (R)-2-[[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole Sodium Salt; Pariet (R)-Enantiomer; LY307640 (R)-Form; Sodium (R)-Rabeprazole
EINECS	Contact for details

Quality Control

Our (R)-Rabeprazole is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D use. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.