Description

(S)-Rabeprazole CAS NO 177795-59-4 is the pharmacologically active enantiomer of the proton pump inhibitor rabeprazole, offering a targeted mechanism for gastric acid suppression. This high-purity chiral intermediate is critical for the development of enantiomerically pure active pharmaceutical ingredients (APIs) with enhanced efficacy and reduced side-effect profiles. It is primarily required by pharmaceutical R&D laboratories and manufacturers specializing in advanced gastrointestinal therapeutics and novel drug formulations.

Application

• Key chiral building block for the synthesis of enantiopure Rabeprazole Sodium API.
• Critical intermediate in the research and development of next-generation proton pump inhibitors (PPIs) with improved pharmacokinetic profiles.
• Used in analytical method development as a reference standard for chiral separation and purity assessment.
• Essential material for pharmacology and toxicology studies investigating the specific effects of the (S)-enantiomer.
• Employed in the production of specialized pharmaceutical formulations targeting gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome.

Basic Information

Product Name	(S)-Rabeprazole
CAS No.	177795-59-4
Molecular Formula	C18H20N3NaO3S
Molecular Weight	381.42 g/mol
Synonyms	(S)-Rabeprazole; Dexrabeprazole; (S)-2-[[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole Sodium Salt; (S)-Rabeprazole Sodium; Dexlansoprazole Impurity; Pariprazole (S-enantiomer); LY307640 (S-form)
EINECS	Contact for details

Quality Control

Our (S)-Rabeprazole is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0%
Single Maximum Impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.