Description

β-Hydroxypropyl-Cyclodextrin is a chemically modified cyclodextrin derivative, specifically engineered to enhance the solubility and stability of poorly water-soluble compounds. This modification is critical for improving the bioavailability and delivery of active ingredients in pharmaceutical and nutraceutical formulations. It is an essential excipient for formulation scientists and process engineers in the pharmaceutical, cosmetic, and food industries seeking advanced drug delivery solutions.

Application

• Pharmaceutical Solubilizer & Stabilizer: Enhances the aqueous solubility and chemical stability of active pharmaceutical ingredients (APIs) in injectable, oral, and topical formulations.
• Drug Delivery Systems: Serves as a key component in the development of inclusion complexes for controlled and targeted drug release.
• Cosmetic Ingredient Carrier: Improves the delivery and efficacy of vitamins, fragrances, and other active compounds in skincare and personal care products.
• Food & Nutraceutical Encapsulation: Used to mask unpleasant tastes, odors, and to protect sensitive nutrients like vitamins and flavors from degradation.
• Analytical Chemistry: Employed as a chiral selector in capillary electrophoresis and HPLC for the separation of enantiomers.
• Catalyst & Reaction Media: Acts as a supramolecular host in green chemistry applications to facilitate organic reactions in aqueous media.

Basic Information

Product Name	β-Hydroxypropyl-Cyclodextrin
CAS No.	177317-02-1
Molecular Formula	C63H112O35 (Parent β-Cyclodextrin core with hydroxypropyl substitutions; exact formula varies with degree of substitution)
Molecular Weight	~1400 g/mol (Average, dependent on molar substitution)
Synonyms	2-Hydroxypropyl-β-cyclodextrin; HP-β-CD; Hydroxypropyl Betadex; Hydroxypropyl-β-cyclodextrin; (2-Hydroxypropyl)-β-cyclodextrin; β-Cyclodextrin, 2-hydroxypropyl ether; Heptakis(2-hydroxypropyl)-β-cyclodextrin (for specific DS); Kleptose® HPB (Roquette trade name); Encapsin® HPB
EINECS	Contact for details

Quality Control

Our β-Hydroxypropyl-Cyclodextrin is manufactured under a quality management system and undergoes rigorous analytical testing to ensure batch-to-batch consistency and compliance with relevant standards for pharmaceutical and food-grade applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing parameters such as assay, degree of substitution, residue on ignition, and microbial limits. We can supply material compliant with USP/NF, EP, and FCC monographs upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed after initial use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White or almost white powder
Identification (IR)	Conforms
Assay (HP-β-CD Content)	≥ 98.0% (on dried basis)
Degree of Substitution (Molar Substitution)	0.6 - 1.0 (or as specified)
Water Content (Karl Fischer)	≤ 10.0 %
Residue on Ignition	≤ 0.1 %
Heavy Metals	≤ 10 ppm
Microbial Limits	Conforms to USP/EP requirements
pH (10% solution)	5.0 - 7.5

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.