Description

Azide-PEG2-Ms is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an azide group and a mesylate leaving group. This compound is a critical reagent in bioconjugation and click chemistry, enabling the efficient, site-specific modification of biomolecules and surfaces under mild conditions. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and materials science who require reliable, high-purity linkers for constructing complex molecular architectures, such as antibody-drug conjugates (ADCs) and PEGylated therapeutics.

Application

• Bioconjugation and ADC Development: Site-specific coupling of payloads (e.g., toxins, dyes, drugs) to antibodies, proteins, or peptides via copper-free click chemistry.
• PEGylation and Linker Chemistry: Serving as a functionalized PEG spacer to improve the pharmacokinetic properties of therapeutic agents.
• Surface Functionalization: Modifying nanoparticles, biosensors, or microarray surfaces with azide groups for subsequent bio-orthogonal labeling.
• Polymer and Materials Science: A key monomer or crosslinking agent in the synthesis of functional hydrogels and smart polymeric materials.
• Chemical Biology Probes: Synthesis of activity-based probes for studying enzyme function and metabolic pathways in living systems.
• Diagnostic Reagent Synthesis: Creating labeled antibodies or antigens for immunoassays and diagnostic kits.

Basic Information

Product Name	Azide-PEG2-Ms
CAS No.	176520-23-3
Molecular Formula	C8H17N3O5S
Molecular Weight	267.30 g/mol
Synonyms	2-[2-(2-Azidoethoxy)ethoxy]ethyl methanesulfonate; Azido-PEG2-mesylate; 1-Azido-3,6-dioxaoctyl methanesulfonate; 11-Azido-3,6,9-trioxaundecan-1-yl methanesulfonate; PEG2-Azide-Ms; MsO-PEG2-N3; Methanesulfonic acid 2-[2-(2-azidoethoxy)ethoxy]ethyl ester; Azido-PEG2-OMs
EINECS	Contact for details

Quality Control

Our Azide-PEG2-Ms is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for sensitive research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.