Description

Dimethyl ((3S)-4-Phenyl-3-(Boc-Amino)-2-Oxobutyl)Phosphonate is a high-value, chiral phosphonate building block used in advanced organic synthesis. This compound is critical for the efficient construction of complex molecules, particularly in the development of pharmaceuticals and bioactive compounds. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of peptide mimetics, enzyme inhibitors, and other novel therapeutic agents where precise stereochemistry is essential.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the synthesis of protease inhibitors and other active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used to incorporate non-hydrolyzable phosphonate groups into peptide backbones for creating stable enzyme inhibitors.
• Medicinal Chemistry: Serves as a versatile building block for structure-activity relationship (SAR) studies and lead optimization.
• Asymmetric Synthesis: Employed in Horner-Wadsworth-Emmons (HWE) olefination reactions to generate chiral α,β-unsaturated carbonyl compounds with high stereoselectivity.
• Chemical Biology: Useful for labeling and probing biological systems due to its stable phosphonate moiety.

Basic Information

Product Name	Dimethyl ((3S)-4-Phenyl-3-(Boc-Amino)-2-Oxobutyl)Phosphonate
CAS No.	176504-90-8
Molecular Formula	C₁₇H₂₆NO₆P
Molecular Weight	371.37 g/mol
Synonyms	Dimethyl (3S)-3-[(tert-Butoxycarbonyl)amino]-4-phenyl-2-oxobutylphosphonate; (3S)-3-[(tert-Butoxycarbonyl)amino]-4-phenyl-2-oxobutylphosphonic Acid Dimethyl Ester; Boc-Phe-P(O)(OMe)₂ Ketone; (S)-Dimethyl (3-(Boc-amino)-4-phenyl-2-oxobutyl)phosphonate; N-Boc-L-Phenylalaninal Phosphonate Dimethyl Ester; Chiral β-Ketophosphonate; CAS 176504-90-8
EINECS	Contact for details

Quality Control

Our Dimethyl ((3S)-4-Phenyl-3-(Boc-Amino)-2-Oxobutyl)Phosphonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and NMR for structural confirmation, to meet the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.