Description

cis-Terbinafine Hydrochloride is a high-purity, stereochemically defined active pharmaceutical ingredient (API) and key intermediate. This compound is essential for the research, development, and production of potent antifungal agents, offering a critical building block for targeted therapeutic synthesis. It is primarily required by pharmaceutical manufacturers, R&D laboratories, and fine chemical producers focused on antifungal drug development and advanced chemical synthesis.

Application

• Pharmaceutical API Synthesis: Primary use as the active pharmaceutical ingredient or a critical intermediate in the manufacture of antifungal medications.
• Antifungal Drug Development: Serves as a key reference standard and starting material in R&D for novel topical and systemic antifungal therapies.
• Biochemical Research: Used in pharmacological studies to investigate mechanisms of action against fungal pathogens like dermatophytes and yeasts.
• Fine Chemical Intermediate: Employed in multi-step organic synthesis to create more complex molecules with specific biological activity.
• Veterinary Medicine: Potential application in developing antifungal treatments for animal health.
• Reference Standard: Utilized in analytical laboratories for method development, validation, and quality control testing of related products.

Basic Information

Product Name	cis-Terbinafine Hydrochloride
CAS No.	176168-78-8
Molecular Formula	C21H26ClN • HCl
Molecular Weight	368.35 g/mol
Synonyms	(2E)-6,6-Dimethyl-2-hepten-4-yn-1-amine, (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-1-naphthalenemethanamine hydrochloride, Terbinafine cis-isomer hydrochloride, (E)-N-(6,6-Dimethyl-2-hepten-4-yn-1-yl)-1-naphthalenemethanamine hydrochloride, Lamisil intermediate, Antifungal intermediate
EINECS	Contact for details

Quality Control

Our cis-Terbinafine Hydrochloride is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets high-purity standards suitable for pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (cis-isomer)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.