Description

2'-O-Methyl Isocytidine is a chemically modified nucleoside analog, a key building block in oligonucleotide synthesis. This compound is critical for the development of antisense oligonucleotides, siRNA, and other therapeutic nucleic acids, where it enhances stability and modulates biological activity. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on advanced genetic medicine and molecular biology.

Application

• Oligonucleotide Synthesis: A vital phosphoramidite monomer for the solid-phase synthesis of modified RNA and DNA strands.
• Antisense Therapy Development: Used to create nuclease-resistant oligonucleotides for targeting specific mRNA sequences.
• siRNA and miRNA Research: Incorporated to improve the pharmacokinetic profile and potency of RNA interference (RNAi) agents.
• Structural Biology Studies: Employed to investigate RNA structure, function, and protein-nucleic acid interactions.
• Diagnostic Probe Design: Serves as a component in the manufacture of high-specificity probes for molecular diagnostics.
• Pharmaceutical Intermediates: Acts as a sophisticated intermediate in the synthesis of novel nucleoside-based antiviral or anticancer prodrugs.

Basic Information

Product Name	2'-O-Methyl Isocytidine
CAS No.	175471-65-5
Molecular Formula	C10H15N3O5
Molecular Weight	257.24 g/mol
Synonyms	2'-O-Methyl-5-methylisocytidine; 1-(2-O-Methyl-β-D-ribofuranosyl)-4-amino-2(1H)-pyrimidinone; 4-Amino-1-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl)pyrimidin-2-one; 2'-OMe-iC; 2'-O-Me-isocytidine; Isocytidine, 2'-O-methyl-; 2'-O-Methyl-N4-methylisocytidine (common misnomer); 2'-O-Methyl-5-methyl-isoC
EINECS	Contact for details

Quality Control

Our 2'-O-Methyl Isocytidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and LC-MS for identity, ensuring it meets the high standards required for pharmaceutical research and oligonucleotide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.