Description

Voreloxin is a synthetic small molecule compound belonging to the class of topoisomerase II inhibitors. This product is of significant interest for its role in advanced pharmaceutical research and development, particularly in the field of oncology. It is primarily utilized by research institutions, pharmaceutical developers, and contract manufacturing organizations (CMOs) engaged in the synthesis of novel therapeutic agents. The material is supplied with a focus on high purity and batch-to-batch consistency to support critical preclinical and clinical studies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs) for oncology research.
• Biochemical Research: Used as a reference standard or tool compound in studies investigating topoisomerase II inhibition and DNA damage response pathways.
• Preclinical Development: Employed in formulation studies and pharmacokinetic/pharmacodynamic (PK/PD) modeling for new drug candidates.
• Anticancer Agent Research: Fundamental material for in vitro and in vivo studies targeting various cancer cell lines, including acute myeloid leukemia (AML).
• Contract Manufacturing: Supplied to CMOs and CDMOs for scale-up synthesis under current Good Manufacturing Practice (cGMP) guidelines for clinical trial material production.

Basic Information

Product Name	Voreloxin
CAS No.	175414-77-4
Molecular Formula	C₂₄H₂₈N₄O₄
Molecular Weight	436.50 g/mol
Synonyms	Voreloxin; AG-7352; (7S,9S)-7-[(2R,4S,5R,6S)-4-Amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione; Quinobenzoxazine derivative; NSC 726281; Topoisomerase II inhibitor AG-7352
EINECS	Contact for details

Quality Control

Every batch of Voreloxin is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical development. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles. We support development with material suitable for research use and can provide material manufactured under cGMP guidelines for advanced clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	<20 ppm
Related Substances (HPLC)	Total impurities <2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.