Description

5-Methyl-2-(trifluoromethyl)furan-3-carbonyl chloride is a highly reactive and versatile chemical building block, specifically an acid chloride derivative of a substituted furan carboxylic acid. Its primary value lies in its role as a key synthetic intermediate for constructing more complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), advanced materials, and specialty fine chemicals, where the introduction of the trifluoromethyl and furan motifs is critical for modulating biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and biological efficacy.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, coatings, and liquid crystals with unique thermal and chemical resistance.
• Organic Synthesis Reagent: Employed in academic and industrial R&D for amide bond formation, Friedel-Crafts acylation, and other nucleophilic substitution reactions to create complex heterocyclic compounds.
• Fluorine Chemistry Research: An important substrate for studying the effects of fluorine substitution on reaction pathways and molecular properties in medicinal and synthetic chemistry.

Basic Information

Product Name	5-Methyl-2-(trifluoromethyl)furan-3-carbonyl chloride
CAS No.	175276-66-1
Molecular Formula	C7H4ClF3O2
Molecular Weight	212.56 g/mol
Synonyms	3-Furoyl chloride, 5-methyl-2-(trifluoromethyl)-; 5-Methyl-2-(trifluoromethyl)-3-furoyl chloride; 2-(Trifluoromethyl)-5-methylfuran-3-carbonyl chloride; 5-Methyl-2-trifluoromethylfuran-3-carbonyl chloride; 175276-66-1; 5-Methyl-2-(trifluoromethyl)-3-furancarbonyl chloride
EINECS	Contact for details

Quality Control

Our production of 5-Methyl-2-(trifluoromethyl)furan-3-carbonyl chloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC to confirm identity, potency, and impurity profiles. Certificates of Analysis (COA) documenting all critical quality attributes are provided with every shipment. We operate under a cGMP-compliant quality system suitable for supporting pharmaceutical development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.