Description

2-Chloro-4-(Trifluoromethyl)Phenyl Isothiocyanate is a specialized organic building block characterized by its reactive isothiocyanate functional group. This compound is of significant value in advanced organic synthesis, serving as a key precursor for the development of heterocyclic compounds and functional materials. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for enhanced bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalysis and material science applications.
• Heterocyclic Chemistry: A versatile reagent for constructing sulfur and nitrogen-containing heterocycles, which are core structures in many functional molecules.
• Chemical Biology Research: Employed as a probe or labeling agent in biochemical studies due to its reactive isothiocyanate group, which can bind to amines.
• Material Science: Investigated for the synthesis of advanced polymers or functional surfaces with specific chemical properties.

Basic Information

Product Name	2-Chloro-4-(Trifluoromethyl)Phenyl Isothiocyanate
CAS No.	175205-38-6
Molecular Formula	C8H3ClF3NS
Molecular Weight	237.63 g/mol
Synonyms	2-Chloro-α,α,α-trifluoro-p-tolyl isothiocyanate; 1-Chloro-4-isothiocyanato-2-(trifluoromethyl)benzene; 2-Chloro-4-(trifluoromethyl)benzenisothiocyanate; 4-Chloro-3-(trifluoromethyl)phenyl isothiocyanate; 2-Chloro-α,α,α-trifluoro-4-isothiocyanatotoluene; 2-Chloro-4-trifluoromethylphenyl isothiocyanate; Isothiocyanic acid, 2-chloro-4-(trifluoromethyl)phenyl ester
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(Trifluoromethyl)Phenyl Isothiocyanate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. All production follows current Good Manufacturing Practices (cGMP) where applicable. Comprehensive analytical testing, including HPLC, GC, and NMR, is performed to verify identity, purity, and impurity profiles. Certificates of Analysis (COA) are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.