Description

4-(Isopropylsulphonyl)Thiophene-2-Carbonyl Chloride is a high-value, reactive chemical intermediate characterized by its sulfonyl and acid chloride functional groups. This compound is critical for introducing the 4-(isopropylsulfonyl)thiophene moiety into target molecules, enabling the synthesis of complex structures with specific electronic and steric properties. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the thiophene scaffold for bioactivity.
• Material Science Research: Serves as a precursor for functionalized polymers, liquid crystals, or organic electronic materials due to the conjugated thiophene system.
• Chemical Biology Probes: Employed in the creation of molecular probes and labeled compounds for biochemical and pharmacological studies.
• Custom Synthesis & Contract Manufacturing: A vital reagent for fine chemical suppliers and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	4-(Isopropylsulphonyl)Thiophene-2-Carbonyl Chloride
CAS No.	175202-47-8
Molecular Formula	C9H11ClO3S2
Molecular Weight	266.77 g/mol
Synonyms	4-(1-Methylethylsulfonyl)-2-thiophenecarbonyl chloride; 2-Thiophenecarbonyl chloride, 4-[(1-methylethyl)sulfonyl]-; 4-(Isopropylsulfonyl)thiophene-2-carbonyl chloride; 4-(Propan-2-ylsulfonyl)thiophene-2-carbonyl chloride; 4-Isopropylsulfonylthiophene-2-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our production of 4-(Isopropylsulphonyl)Thiophene-2-Carbonyl Chloride adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment, supporting compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening and protected from moisture. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.