Description

2-[(4-Methylphenyl)Thio]Pyridine-3-Carbonyl Chloride is a high-purity, reactive chemical intermediate essential for advanced organic synthesis. This compound matters as a key building block for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce specific thioether and carbonyl chloride functionalities into their target structures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides, where its structural motif can contribute to biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials that require specific aromatic heterocycles.
• Custom Synthesis & Contract Manufacturing: A valuable reagent for fine chemical and CDMO (Contract Development and Manufacturing Organization) companies offering bespoke synthesis services.

Basic Information

Product Name	2-[(4-Methylphenyl)Thio]Pyridine-3-Carbonyl Chloride
CAS No.	175135-78-1
Molecular Formula	C13H10ClNOS
Molecular Weight	263.74 g/mol
Synonyms	3-Pyridinecarbonyl chloride, 2-[(4-methylphenyl)thio]-; 2-(p-Tolylthio)nicotinoyl chloride; 2-[(4-Methylphenyl)sulfanyl]pyridine-3-carbonyl chloride; 2-(4-Methylphenylthio)nicotinic acid chloride; 175135-78-1; 2-(4-Methylmercaptophenyl)pyridine-3-carbonyl chloride
EINECS	Contact for details

Quality Control

Our 2-[(4-Methylphenyl)Thio]Pyridine-3-Carbonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to reliable supply and batch-to-batch consistency supports your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.