Description

S-[2-(Iodo-4-Azidosalicylamido)Ethylthio]-2-Thiopyridine is a specialized heterobifunctional crosslinking reagent designed for photoaffinity labeling and bioconjugation applications. This compound matters for researchers and developers requiring precise, covalent attachment of molecules under controlled, light-activated conditions. It is primarily needed by professionals in pharmaceutical R&D, proteomics, and advanced materials science for studying protein interactions, developing targeted drug delivery systems, and creating novel diagnostic assays.

Application

• Photoaffinity Labeling (PAL): A critical tool for mapping ligand-binding sites on proteins and other biological macromolecules through covalent crosslinking initiated by UV light.
• Bioconjugation and Immobilization: Used to attach proteins, peptides, or other biomolecules to solid supports, polymers, or other proteins for assay development and diagnostic kit manufacturing.
• Chemical Biology and Proteomics Research: Enables the study of transient protein-protein interactions and the identification of novel drug targets within complex biological systems.
• Development of Antibody-Drug Conjugates (ADCs): Serves as a potential linker component for constructing next-generation targeted cancer therapeutics.
• Surface Functionalization: Modifies the surface properties of nanoparticles, biosensors, and medical devices to introduce specific biological activity.
• Crosslinking Agent for Polymer Chemistry: Facilitates the synthesis of novel polymeric materials with light-responsive or bioactive properties.

Basic Information

Product Name	S-[2-(Iodo-4-Azidosalicylamido)Ethylthio]-2-Thiopyridine
CAS No.	175093-14-8
Molecular Formula	C16H13IN5O2S2
Molecular Weight	530.34 g/mol
Synonyms	2-Iodo-4-azidosalicylamidoethyl 2-Pyridyldisulfide; Iodoazidosalicylamidoethyl 2-Pyridyldisulfide; IASD-OPSS; S-[2-[(2-Iodo-4-azidophenyl)formamido]ethylthio]-2-thiopyridine; 4-Azido-2-iodosalicylamidoethyl 2-Pyridyldisulfide; Heterobifunctional Crosslinker IASD-OPSS; Photoactivatable OPSS Reagent; N-[2-[(2-Pyridinyldithio)ethyl]-4-azido-2-iodobenzamide
EINECS	Contact for details

Quality Control

Our production of S-[2-(Iodo-4-Azidosalicylamido)Ethylthio]-2-Thiopyridine adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and spectroscopic methods for structural confirmation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant in a freezer dedicated for chemicals. This compound is both light-sensitive (store away from light) and hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term stability, store under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	Light yellow to yellow solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.