Description

(R)-[3-(3-Fluoro-4-Morpholinophenyl)-2-Oxo-5-Oxazolidinyl]Methyl Methanesulfonate is a high-purity, non-racemic chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters because it serves as a critical building block for the production of novel antibacterial agents, particularly within the oxazolidinone class. Pharmaceutical R&D and manufacturing teams need this specific enantiomer to develop and produce potent, targeted therapeutics with improved efficacy and safety profiles.

Application

• Key Intermediate for Antibacterial API Synthesis: Primarily used in the research and commercial-scale production of next-generation oxazolidinone antibiotics.
• Chiral Building Block in Medicinal Chemistry: Enables the construction of complex, stereochemically defined molecular architectures in drug discovery programs.
• Process Chemistry & Scale-Up: Serves as a defined starting material or intermediate in optimized chemical process routes for Active Pharmaceutical Ingredients (APIs).
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and impurity profiling.
• Academic & Contract Research: Facilitates biochemical and pharmacological research into novel mechanisms of antibacterial action.

Basic Information

Product Name	(R)-[3-(3-Fluoro-4-Morpholinophenyl)-2-Oxo-5-Oxazolidinyl]Methyl Methanesulfonate
CAS No.	174649-09-3
Molecular Formula	C15H19FN2O6S
Molecular Weight	374.39 g/mol
Synonyms	(R)-Linezolid Intermediate; (R)-PNU-100766 Methanesulfonate; (R)-3-[4-[(5S)-5-(Methanesulfonyloxymethyl)-2-oxo-1,3-oxazolidin-3-yl]-3-fluorophenyl]morpholine; (5R)-5-[(Methylsulfonyloxy)methyl]-3-(3-fluoro-4-morpholinophenyl)-1,3-oxazolidin-2-one; (R)-Linezolid Mesylate Intermediate; PNU-100766 (R-enantiomer) Mesylate; (R)-Oxazolidinone Antibacterial Intermediate
EINECS	Contact for details

Quality Control

Our (R)-[3-(3-Fluoro-4-Morpholinophenyl)-2-Oxo-5-Oxazolidinyl]Methyl Methanesulfonate is manufactured under strict quality systems to ensure batch-to-batch consistency and high enantiomeric purity. Products undergo rigorous analytical testing, including chiral HPLC, NMR, and MS, to ensure compliance with stringent pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >98.5%), chiral purity (>99.0% ee), and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere or with appropriate desiccant to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Any individual impurity ≤ 0.5% Total impurities ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.