Description

2'-Amino-2'-Deoxy-5'-o-(4,4'-Dimethoxytrityl)Uridine is a key nucleoside derivative, specifically a protected uridine analog, widely used as a critical building block in oligonucleotide synthesis. Its primary value lies in enabling the precise construction of modified nucleic acid sequences for advanced research and therapeutic development. This high-purity intermediate is essential for pharmaceutical R&D, biotechnology companies, and academic institutions focused on antisense oligonucleotides, siRNA, and other nucleic acid-based technologies.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): Serves as a protected phosphoramidite precursor for the automated synthesis of DNA/RNA strands containing modified bases.
• Antisense Oligonucleotide (ASO) Development: Used to incorporate specific modifications that enhance target binding affinity, stability, and pharmacokinetic properties of therapeutic ASOs.
• siRNA and miRNA Research: A crucial reagent for constructing chemically modified small interfering RNA (siRNA) and microRNA (miRNA) molecules to improve nuclease resistance and efficacy.
• Diagnostic Probe Synthesis: Employed in the manufacture of labeled probes and primers for molecular diagnostics, including PCR and hybridization assays.
• Medicinal Chemistry & Drug Discovery: Acts as a scaffold for developing novel nucleoside-based therapeutics targeting viral infections and genetic disorders.
• Academic & Industrial R&D: Fundamental research tool for studying nucleic acid structure, function, and for exploring new gene silencing strategies.

Basic Information

Product Name	2'-Amino-2'-Deoxy-5'-o-(4,4'-Dimethoxytrityl)Uridine
CAS No.	174221-86-4
Molecular Formula	C30H31N3O7
Molecular Weight	545.59 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-amino-2'-deoxyuridine; 2'-Amino-2'-deoxy-5'-O-DMT-uridine; DMT-2'-NH2-2'-dU; 2'-Amino-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine; 2'-Amino-2'-deoxyuridine 5'-O-(4,4'-dimethoxytrityl) ether; 2'-Amino-5'-O-DMT-2'-deoxyuridine; N3-2'-Amino-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine
EINECS	Contact for details

Quality Control

Our 2'-Amino-2'-Deoxy-5'-o-(4,4'-Dimethoxytrityl)Uridine is manufactured under strict quality systems to ensure consistency and reliability for sensitive synthetic applications. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation. Comprehensive Certificates of Analysis (COA) detailing purity, moisture content, and related substances are provided to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.