Description

1-Chloro-5-Triethylsilyl-4-Pentyne is a specialized organosilicon building block featuring both a terminal alkyne and a reactive chloroalkyl group. This bifunctional molecular architecture makes it a highly versatile intermediate for constructing complex organic frameworks through sequential coupling and functionalization reactions. It is primarily utilized by pharmaceutical researchers and advanced material scientists in the development of novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key synthon for constructing complex drug candidates, particularly in medicinal chemistry programs targeting new therapeutic entities.
• Organic Synthesis Building Block: Used in Sonogashira, Heck, and other cross-coupling reactions to introduce alkyne and silyl-protected functionalities.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty silicon-containing polymers and dendrimers.
• Agrochemical Research: Employed in the development of novel crop protection agents and plant growth regulators.
• Ligand Synthesis: Useful for preparing sophisticated ligands for catalysis and coordination chemistry.
• Chemical Biology Probes: Facilitates the synthesis of tagged molecules for studying biological pathways and interactions.

Basic Information

Product Name	1-Chloro-5-Triethylsilyl-4-Pentyne
CAS No.	174125-30-5
Molecular Formula	C11H21ClSi
Molecular Weight	216.82 g/mol
Synonyms	5-(Chloro)-1-(triethylsilyl)-1-pentyne; 1-Pentyne, 5-chloro-1-(triethylsilyl)-; 5-Chloro-1-(triethylsilyl)-1-pentyne; (5-Chloropent-1-yn-1-yl)triethylsilane; Triethyl((5-chloropent-1-yn-1-yl))silane; 5-Chloro-1-triethylsilyl-1-pentyne; TES-Protected 5-Chloro-1-pentyne; Chloro(triethylsilyl)pentyne
EINECS	Contact for details

Quality Control

Our 1-Chloro-5-Triethylsilyl-4-Pentyne is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications in GMP-compliant research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.