Description

3,5-Bis(Trifluoromethyl)Phenylacetyl Chloride is a high-value, reactive chemical intermediate characterized by its phenylacetyl chloride core flanked by two trifluoromethyl groups. This structure is critical for introducing lipophilic and electron-withdrawing properties into target molecules, significantly enhancing their metabolic stability and bioavailability. It is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical sectors for the synthesis of advanced active ingredients and novel compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl groups improve efficacy and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of novel polymers, liquid crystals, and organic electronic materials with tailored properties.
• Custom Synthesis & Contract Manufacturing: A vital reagent for fine chemical and CDMO (Contract Development and Manufacturing Organization) facilities producing bespoke compounds for clients.
• Fluorinated Compound Libraries: Essential for medicinal chemistry teams building screening libraries to explore structure-activity relationships (SAR) around fluorinated motifs.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Phenylacetyl Chloride
CAS No.	174083-39-7
Molecular Formula	C10H5ClF6O
Molecular Weight	290.59 g/mol
Synonyms	2-[3,5-Bis(trifluoromethyl)phenyl]acetyl chloride; 3,5-Bis(trifluoromethyl)benzeneacetyl chloride; (3,5-Bis(trifluoromethyl)phenyl)acetic acid chloride; α-Chloro-3,5-bis(trifluoromethyl)acetophenone; 3,5-Di(trifluoromethyl)phenylacetyl chloride; 2-(3,5-Bis(trifluoromethyl)phenyl)acetyl chloride; 3,5-Bis(trifluoromethyl)phenacyl chloride
EINECS	Contact for details

Quality Control

Our 3,5-Bis(Trifluoromethyl)Phenylacetyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening and protected from moisture. Keep away from strong bases, oxidizers, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.