Description

4'-C-Azido-2'-Deoxy-2'-Fluoro-β-D-Arabinouridine is a high-purity nucleoside analog building block of significant interest in advanced pharmaceutical research and development. This modified nucleoside is a critical intermediate in the synthesis of novel antiviral and anticancer therapeutics, particularly within the field of oligonucleotide chemistry. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who are developing next-generation nucleic acid-based drugs.

Application

• Antiviral Drug Synthesis: A key precursor in the development of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral agents.
• Anticancer Prodrug Development: Used in the research and synthesis of prodrugs targeting various cancer pathways.
• Oligonucleotide & Antisense Therapy: Serves as a modified building block for the solid-phase synthesis of therapeutic oligonucleotides, including antisense and siRNA molecules.
• Medicinal Chemistry Research: A valuable tool for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Bioconjugation & Probe Development: The azido functional group enables click chemistry for labeling and conjugating biomolecules for diagnostic and research applications.
• Process Chemistry & Scale-Up: Supplied for GMP and non-GMP scale-up processes from laboratory to pilot plant and commercial manufacturing.

Basic Information

Product Name	4'-C-Azido-2'-Deoxy-2'-Fluoro-β-D-Arabinouridine
CAS No.	173379-73-2
Molecular Formula	C9H10FN5O5
Molecular Weight	287.21 g/mol
Synonyms	4'-Azido-2'-deoxy-2'-fluoroarabinouridine; 2'-Deoxy-2'-fluoro-4'-azido-β-D-arabinouridine; 4'-Azido-2'-deoxy-2'-fluoro-β-D-arabinofuranosyluracil; 4'-C-N3-2'-F-ara-U; 4'-Azido-FAU; 1-(4-Az-2-deoxy-2-fluoro-β-D-arabinofuranosyl)uracil; 4'-Azido-2'-fluoro-2'-deoxyarabinouridine
EINECS	Contact for details

Quality Control

Our 4'-C-Azido-2'-Deoxy-2'-Fluoro-β-D-Arabinouridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.