Description

2,4(1H,3H)-Pyrimidinedione, 1-[4-C-Azido-2,5-Dideoxy-2-Fluoro-5-Iodo-β-D-Arabinofuranosyl]- is a sophisticated nucleoside analog, specifically a fluorinated and iodinated arabinofuranosyl uracil derivative bearing an azido functional group. This compound is of critical importance as a key intermediate and building block in the synthesis of novel antiviral and anticancer agents, particularly in the development of modified nucleosides for targeted therapies. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on medicinal chemistry and drug discovery.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel antiviral drugs, particularly those targeting viral polymerases.
• Anticancer Agent Research: Serves as a building block for developing nucleoside analogs that inhibit cancer cell proliferation.
• Medicinal Chemistry Probe: Used in structure-activity relationship (SAR) studies to understand the impact of fluorine, iodine, and azido modifications on biological activity.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog for nucleoside-metabolizing enzymes.
• Labeled Compound Synthesis: The azido and halogen groups provide handles for further chemical modifications, including "click chemistry" conjugation for creating labeled probes.
• Radiopharmaceutical Precursor: The iodine atom presents potential for radioiodination, making it a candidate precursor for diagnostic imaging agents.

Basic Information

Product Name	2,4(1H,3H)-Pyrimidinedione, 1-[4-C-Azido-2,5-Dideoxy-2-Fluoro-5-Iodo-β-D-Arabinofuranosyl]-
CAS No.	173379-67-4
Molecular Formula	C9H9FN5O4I
Molecular Weight	421.10 g/mol
Synonyms	1-(4-Azido-2,5-dideoxy-2-fluoro-5-iodo-β-D-arabinofuranosyl)uracil; 4-Azido-2,5-dideoxy-2-fluoro-5-iodo-β-D-arabinofuranosyluracil; 2'-Fluoro-5'-iodo-4'-azido-ara-U; 4'-Azido-2'-fluoro-5'-iodo-arabinofuranosyluracil; 1-(4-Azido-2-deoxy-2-fluoro-5-iodo-β-D-arabinofuranosyl)uracil; FIAU-Azide (context-specific); 173379-67-4 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems. Each batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The compound is both light-sensitive and moisture-sensitive; allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.