Description

Aliskiren CAS NO 173334-57-1 is a potent, direct renin inhibitor used as an active pharmaceutical ingredient (API). This compound is critical for the development and production of antihypertensive medications, offering a specific mechanism of action for blood pressure management. It is primarily required by pharmaceutical manufacturers and research institutions engaged in cardiovascular drug development and formulation.

Application

• Pharmaceutical API: Primary use as the active ingredient in antihypertensive medications for the treatment of hypertension.
• Drug Formulation: Used in the development and production of solid oral dosage forms such as tablets and capsules.
• Clinical Research: Serves as a reference standard and investigational compound in cardiovascular disease studies.
• Biochemical Research: Utilized in pharmacological studies to investigate the renin-angiotensin-aldosterone system (RAAS).
• Generic Drug Manufacturing: Essential for the production of generic versions of aliskiren-based medications.
• Analytical Testing: Employed as a high-purity standard in quality control laboratories for HPLC and other analytical methods.

Basic Information

Product Name	Aliskiren
CAS No.	173334-57-1
Molecular Formula	C30H53N3O6
Molecular Weight	551.76 g/mol
Synonyms	Aliskiren Hemifumarate; SPP100; CGP 60536; (2S,4S,5S,7S)-N-(2-Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]octanamide hemifumarate; Tekturna (Brand Name); Rasilez (Brand Name); Renin Inhibitor SPP100; (2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]octanamide hemifumarate
EINECS	Contact for details

Quality Control

Our Aliskiren is manufactured under strict quality management systems to ensure it meets the high standards required for pharmaceutical applications. Each batch is tested against comprehensive specifications, including identity, purity, and impurity profiles, using validated analytical methods such as HPLC. Certificates of Analysis (COA) are provided and can be tailored to meet specific pharmacopeial requirements (e.g., USP, EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider conditions with low humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.