Description

5'-O-(4,4'-Dimethoxytrityl)-2,2'-Anhydro-D-Uridine is a sophisticated nucleoside derivative and a critical protected intermediate in oligonucleotide synthesis. This compound matters because it enables the precise and efficient construction of RNA sequences, a foundational process in modern life sciences research and therapeutic development. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic laboratories focused on antisense technology, siRNA development, and other nucleic acid-based applications.

Application

• Solid-Phase Oligonucleotide Synthesis: A key phosphoramidite precursor for the automated synthesis of RNA strands.
• Antisense Oligonucleotide (ASO) Development: Used in the research and production of therapeutic ASOs targeting genetic diseases.
• Small Interfering RNA (siRNA) Manufacturing: Essential building block for creating siRNA duplexes used in gene silencing studies and RNAi therapeutics.
• Research-scale RNA Probe Synthesis: For creating labeled or modified RNA probes used in diagnostics and molecular biology assays.
• Nucleic Acid Chemistry Research: Serves as a model compound for studying nucleoside protection strategies and reaction mechanisms.
• GMP-grade Therapeutic Oligonucleotide Production: High-purity grades support cGMP manufacturing of clinical trial materials and approved drugs.

Basic Information

Product Name	5'-O-(4,4'-Dimethoxytrityl)-2,2'-Anhydro-D-Uridine
CAS No.	173170-12-2
Molecular Formula	C32H32N2O8
Molecular Weight	572.61 g/mol
Synonyms	5'-O-DMT-2,2'-Anhydro-D-Uridine; 5'-O-(4,4'-Dimethoxytrityl)-2,2'-anhydro-1-β-D-ribofuranosyluracil; DMT-AnhydroUridine; 2,2'-Anhydro-5'-O-(4,4'-dimethoxytrityl)uridine; 1-(5-O-[(4,4'-Dimethoxytriphenyl)methyl]-2,3-O-isopropylidene-β-D-ribofuranosyl)-2,2'-anhydrouracil (related protected form); Anhydro-D-Uridine DMT Ether; RNA Phosphoramidite Intermediate
EINECS	Contact for details

Quality Control

Our 5'-O-(4,4'-Dimethoxytrityl)-2,2'-Anhydro-D-Uridine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive oligonucleotide synthesis. Each lot undergoes comprehensive analytical testing including HPLC for purity and identity confirmation (NMR, IR). Certificates of Analysis (COA) with full analytical data are provided and can be tailored to meet specific research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.