Description

β-Phenyl-1,N2-Etheno-8-Bromoguanosine-3',5'-Cyclic Monophosphorothioate, Sp-Isomer Sodium Salt is a chemically modified nucleotide analog designed for advanced biochemical and pharmacological research. This compound is a crucial tool for studying cyclic nucleotide signaling pathways, particularly those involving cGMP-dependent protein kinases (PKG), due to its resistance to hydrolysis by phosphodiesterases. It is primarily utilized by research institutions and pharmaceutical developers focused on cardiovascular, neurological, and metabolic disease research, where precise modulation of intracellular signaling is required.

Application

• Biochemical Research: Acts as a potent and hydrolysis-resistant activator of cGMP-dependent protein kinase (PKG) for studying signal transduction mechanisms.
• Pharmaceutical R&D: Serves as a key reference standard and tool compound in the development of novel therapeutics targeting cyclic nucleotide pathways.
• Cell Signaling Studies: Used to investigate the role of cGMP in processes like vasodilation, platelet aggregation, and neuronal plasticity.
• Enzyme Assay Development: Employed in high-throughput screening (HTS) assays to identify modulators of PKG and related enzymes.
• Metabolic Disorder Research: Applied in studies exploring insulin secretion, smooth muscle relaxation, and other cGMP-mediated physiological functions.
• Probe for Photolabile Caged Compounds: The bromoguanosine and etheno modifications make it a candidate for developing photoactivatable "caged" probes for precise temporal control in live-cell imaging.

Basic Information

Item	Detail
Product Name	β-Phenyl-1,N2-Etheno-8-Bromoguanosine-3',5'-Cyclic Monophosphorothioate, Sp-Isomer Sodium Salt
CAS No.	172806-21-2
Molecular Formula	C18H15BrN5O10P2S • xNa
Molecular Weight	Contact for details
Synonyms	8-Br-PET-cGMPS, Sp-isomer; 8-Bromo-β-phenyl-1,N2-ethenoguanosine-3',5'-cyclic monophosphorothioate, Sp-isomer sodium salt; Sp-8-Bromo-PET-cGMPS; Sp-8-Br-PET-cGMPS sodium salt; cGMP analog, PKG activator; 8-Bromo-β-phenyl-1,N2-etheno-3',5'-cyclic guanosine monophosphorothioate; PET-8-Br-cGMPS(S)
EINECS	Contact for details

Quality Control

Our production of this high-purity biochemical adheres to stringent quality protocols. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, isomeric purity (Sp-isomer), and chemical integrity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to ensure traceability and support your research reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95% (Area %)
Isomeric Purity (Sp-isomer)	≥98%
Water Content (KF)	≤3.0%
Solubility	Soluble in DMSO, Methanol; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.