Description

β-Phenyl-1, N2-Etheno-8-Bromoguanosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt is a chemically modified nucleotide analog of significant value in biochemical and pharmacological research. This compound serves as a potent and selective activator of cyclic GMP-dependent protein kinase (PKG), making it a critical tool for studying intracellular signaling pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in cardiovascular, neurological, and metabolic disease research, as well as in high-throughput screening for drug discovery.

Application

• Biochemical Research: As a cell-permeable, hydrolysis-resistant activator of PKG isoforms (PKG Iα, Iβ, and II) for investigating cGMP-mediated signal transduction.
• Cardiovascular Pharmacology: Used in studies targeting vasodilation, platelet aggregation inhibition, and cardiac protection mechanisms.
• Neuroscience Research: For exploring the role of PKG in synaptic plasticity, nociception, and neurodegenerative disorders.
• Metabolic Disease Studies: Investigation of PKG's function in insulin secretion, glucose homeostasis, and adipocyte biology.
• Drug Discovery & Screening: A key reference compound and positive control in high-throughput assays designed to identify novel PKG modulators.
• Cell Biology: Probing cellular processes such as smooth muscle relaxation, cell proliferation, and apoptosis.

Basic Information

Product Name	β-Phenyl-1, N2-Etheno-8-Bromoguanosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt
CAS No.	172806-20-1
Molecular Formula	C₁₈H₁₅BrN₅O₁₀P₂S • xNa
Molecular Weight	Approx. 690.2 (Free acid) - Contact for exact salt form weight.
Synonyms	8-Br-PET-cGMPS, Rp-isomer; Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3',5'-cyclic monophosphorothioate sodium salt; Rp-8-Br-PET-cGMPS; PKG Activator, Rp-8-Br-PET-cGMPS; (Rp)-8-Bromo-β-phenyl-1,N²-etheno-cyclic GMPS; β-PHENYL-1,N2-ETHENO-8-BROMOGUANOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER; 8-Bromo-β-phenyl-1,N²-ethenoguanosine 3',5'-cyclic monophosphorothioate (Rp-isomer) sodium salt
EINECS	Contact for details.

Quality Control

Our high-purity biochemical reagents are manufactured under strict quality systems. Each batch of β-Phenyl-1, N2-Etheno-8-Bromoguanosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for sensitive research applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in DMSO, Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.