Description

Cyclopropanecarbonyl Chloride, 2-(Phenylethynyl)-, trans- (9Ci) is a specialized, high-purity organic building block featuring a reactive acid chloride group and a rigid, conjugated alkyne-substituted cyclopropane scaffold. This compound matters for its unique structural motif, which enables the synthesis of complex molecules with precise stereochemistry and functional group density. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, leveraging its constrained cyclopropane ring for bioactivity.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials.
• Chemical Biology Probe Synthesis: Employed to create tagged molecules or activity-based probes for studying biological pathways and protein function.
• Catalyst & Ligand Development: Useful for constructing sophisticated chiral ligands and organocatalysts for asymmetric synthesis.
• Academic & Contract Research: Essential reagent for methodological development and exploration of new organic reactions in university and CRO laboratories.

Basic Information

Product Name	Cyclopropanecarbonyl Chloride, 2-(Phenylethynyl)-, trans- (9Ci)
CAS No.	172477-27-9
Molecular Formula	C12H9ClO
Molecular Weight	204.65 g/mol
Synonyms	trans-2-(Phenylethynyl)cyclopropanecarbonyl chloride; (1R,2S)-rel-2-(2-Phenylethynyl)cyclopropanecarbonyl chloride; 2-(Phenylethynyl)cyclopropanecarbonyl chloride, trans-; 172477-27-9; Cyclopropanecarbonyl chloride, 2-(2-phenylethynyl)-, (1R,2S)-rel-; (1R,2S)-2-(Phenylethynyl)cyclopropane-1-carbonyl chloride
EINECS	Contact for details

Quality Control

Every batch of Cyclopropanecarbonyl Chloride, 2-(Phenylethynyl)-, trans- (9Ci) undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment includes strict adherence to in-house specifications developed for research and process chemistry applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC/NMR), identity confirmation, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent hydrolysis of the acid chloride functionality.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.