Description

7-Deaza-7-Iodo-2'-Deoxyguanosine is a modified nucleoside analog, specifically engineered for advanced biochemical and pharmaceutical research applications. This compound is a critical building block in the synthesis of oligonucleotides, enabling the study of nucleic acid structure, function, and therapeutic potential. It is primarily utilized by research institutions, diagnostic developers, and pharmaceutical companies engaged in antiviral drug discovery, molecular probe development, and nucleic acid chemistry.

Application

• Antiviral and Anticancer Nucleoside Analogue Synthesis: Serves as a key precursor in the development of novel therapeutic agents targeting viral polymerases and cellular replication pathways.
• Oligonucleotide Synthesis: Used as a modified phosphoramidite or solid-phase synthesis building block to incorporate specific functionalities into DNA strands for research and diagnostics.
• Biochemical Research & Probe Development: Essential for creating labeled or modified nucleotides used in studying enzyme mechanisms, nucleic acid-protein interactions, and as molecular probes.
• Structural Biology Studies: Incorporated into oligonucleotides to facilitate crystallographic and NMR studies of nucleic acid structures and their complexes.
• Diagnostic Assay Development: Employed in the design of probes for sensitive detection systems, including PCR-based assays and fluorescence in situ hybridization (FISH).

Basic Information

Product Name	7-Deaza-7-Iodo-2'-Deoxyguanosine
CAS No.	172163-62-1
Molecular Formula	C11H13IN4O4
Molecular Weight	392.15 g/mol
Synonyms	7-Iodo-7-deaza-2'-deoxyguanosine; 7-Iodo-7-deazaguanosine 2'-deoxy; 2'-Deoxy-7-iodo-7-deazaguanosine; 7-Deaza-7-iodoguanosine 2'-deoxy; 7-I-7-deaza-dG; 7-Iodo-7-deaza-dG; 7-Deaza-7-iodo-deoxyguanosine; 7-Iodo-7-deazaguanine deoxyriboside
EINECS	Contact for details

Quality Control

Our 7-Deaza-7-Iodo-2'-Deoxyguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.