Description

Darusentan CAS NO 171714-84-4 is a potent and selective endothelin A (ETA) receptor antagonist. This compound is of significant interest in pharmaceutical research and development due to its targeted mechanism of action. It is primarily utilized by researchers and manufacturers in the life sciences sector for investigating cardiovascular pathways and developing novel therapeutic agents.

Application

• Primary research and development of novel cardiovascular therapeutics.
• Investigational studies on endothelin receptor biology and signaling pathways.
• Pre-clinical pharmacological evaluation for hypertension and related disorders.
• Use as a reference standard in analytical method development and validation.
• Biochemical research for studying vascular tone and endothelial function.
• Potential intermediate in the synthesis of more complex pharmaceutical compounds.

Basic Information

Product Name	Darusentan
CAS No.	171714-84-4
Molecular Formula	C29H32N4O6S
Molecular Weight	564.65 g/mol
Synonyms	LU 135252; (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic Acid; Darusentan Hydrate; ETA Receptor Antagonist LU 135252; 1-[2-(Dibutylamino)-2-oxoethyl]-4-(1,3-benzodioxol-5-yl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic Acid
EINECS	Contact for details

Quality Control

Our Darusentan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity analysis, identity confirmation, and impurity profiling to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. Keep the container sealed to protect the product from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.