Description

3-Fluoro-5-(Trifluoromethyl)Benzoyl Chloride is a high-value, multi-fluorinated aromatic acid chloride intermediate. This compound matters for its role as a critical building block in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its unique fluorine substitution pattern imparts desirable properties like metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic cores used in electronic display technologies.
• Polymer Modification: Employed to introduce fluorinated benzoyl groups into polymer chains, altering surface properties and chemical resistance.
• Cross-Coupling Reactions: Acts as an electrophile in palladium-catalyzed reactions like Suzuki or Stille couplings for constructing complex biaryl systems.
• Peptide Mimetic & Proteolysis-Targeting Chimera (PROTAC) Linker Chemistry: Utilized in the construction of sophisticated molecules for targeted protein degradation.

Basic Information

Product Name	3-Fluoro-5-(Trifluoromethyl)Benzoyl Chloride
CAS No.	171243-30-4
Molecular Formula	C8H3ClF4O
Molecular Weight	226.56 g/mol
Synonyms	3-Fluoro-5-(trifluoromethyl)benzoyl chloride; 3-Fluoro-alpha,alpha,α-trifluoro-m-toluoyl chloride; 5-(Trifluoromethyl)-3-fluorobenzoyl chloride; m-Trifluoromethyl-m-fluorobenzoyl chloride; 3-Fluoro-5-trifluoromethylbenzoyl chloride; Benzoyl chloride, 3-fluoro-5-(trifluoromethyl)-; 171243-30-4
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-5-(Trifluoromethyl)Benzoyl Chloride is produced and tested under strict quality management protocols. We ensure high purity and consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by GC, HPLC, and NMR is provided with each shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.