Description

N6-Benzoyl-3'-Deoxy-5'-o-(4,4'-Dimethoxytrityl)-3'-Fluoroadenosine is a sophisticated, high-purity nucleoside derivative, specifically engineered for advanced oligonucleotide synthesis. This compound serves as a critical building block for the solid-phase synthesis of modified DNA and RNA sequences, enabling the creation of stable, nuclease-resistant oligonucleotides. It is an essential raw material for pharmaceutical R&D, particularly in the development of antisense oligonucleotides, siRNA therapeutics, and diagnostic probes for the biotechnology and life sciences sectors.

Application

• Solid-Phase Oligonucleotide Synthesis: A key phosphoramidite precursor for introducing 3'-deoxy-3'-fluoro modifications into DNA/RNA strands.
• Antisense Therapeutic Development: Used in the research and production of antisense drugs that target specific mRNA sequences.
• siRNA and miRNA Synthesis: Critical for manufacturing small interfering RNA (siRNA) and microRNA (miRNA) with enhanced metabolic stability.
• Diagnostic Probe Manufacture: Enables the creation of high-specificity fluorescent or radioactive probes for genetic testing and molecular diagnostics.
• Academic and Pharmaceutical R&D: A vital reagent for studying nucleic acid structure, function, and for drug discovery programs.
• Synthesis of Nucleoside Analogs: Serves as an intermediate for the preparation of other modified nucleosides with potential antiviral or anticancer activity.

Basic Information

Item	Detail
Product Name	N6-Benzoyl-3'-Deoxy-5'-o-(4,4'-Dimethoxytrityl)-3'-Fluoroadenosine
CAS No.	170871-87-1
Molecular Formula	C44H38FN5O7
Molecular Weight	767.80 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-3'-deoxy-3'-fluoroadenosine; 3'-Deoxy-3'-fluoro-N6-benzoyl-5'-O-DMT-adenosine; 3'-Fluoro-3'-deoxy-N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)adenosine; 3'-F-3'-dA(Bz) DMT; DMT-3'-F-dA(Bz); 3'-Fluoro-2',3'-dideoxy-N6-benzoyl-5'-O-DMT-adenosine; 3'-Fluoro-2',3'-didehydro-2',3'-dideoxy-N6-benzoyl-5'-O-DMT-adenosine (related isomer); Protected 3'-Fluoro-2',3'-dideoxyadenosine derivative
EINECS	Contact for details

Quality Control

Our production of N6-Benzoyl-3'-Deoxy-5'-o-(4,4'-Dimethoxytrityl)-3'-Fluoroadenosine adheres to stringent quality protocols suitable for pharmaceutical R&D and GMP starting material applications. Each batch undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. We provide detailed Certificates of Analysis (COA) with batch-specific data to ensure traceability and support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a desiccated environment to prevent degradation due to its hygroscopic and light-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.